Publications

2025년

Lee YB, Kim C, Hong J, Kim D. (2025) Molecular insights into CYP19A1 mutations and their role in estrogen production. Archives of Biochemistry and Biophysics 772, 110573

2023년

Nagayoshi H, Murayama N, Kim V, Kim D, Takenaka S, Yamazaki H, Guengerich FP, Shimada T. (2023) Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1 Chem Res Toxicol (in press)

Kwon YJ, Kwon TU, Shin S, Lee B, Lee H, Park H, Kim D, Moon A, Chun YJ. (2023) Enhancing the invasive traits of breast cancers by CYP1B1 via regulation of p53 to promote uPAR expression. Biochim Biophys Acta Mol Basis Dis 1870(1):166868.

Lee YB, Kim V, Lee SG, Lee GH, Kim C, Jeong E, Kim D. (2023) Functional characterization of allelic variations of human cytochrome P450 2C8 (V181I, I244V, I331T, and L361F). Int J Mol Sci 24(9), 8032

Kim D, Kim S, Kwon Y, Kim Y, Park H, Kwak K, Lee H, Lee JH, Jang KM, Kim D, Lee SH, Kang LW. (2023) Structural insights for β-lactam antibiotics. Biomol Ther 31(2):141-147

Lee SG, Kim V, Lee GH, Kim C, Jeong E, Guengerich FP, Kim D. (2023) Hydroxylation and lyase reactions of steroids catalyzed by mouse cytochrome P450 17A1 (Cyp17a1). J Inorg Biochem. 240, 112085

Lee SA, Kim V, Choi B, Lee H, Chun YJ, Cho KS, Kim D. (2023) Functional characterization of Drosophila melanogaster CYP6A8 fatty acid hydroxylase. Biomol Ther 31(1): 82-88

2022년

Lee S, Park BB, Kwon H, Kim V, Lee R, Subedi M, Lim T, Ha H, Kim D, K S, Kim S, Byun Y. (2022) TNP and its analogs: Modulation of IP6K and CYP3A4 inhibition. J Enzyme Inhib Med Chem 37(1), 269-279

Kim V, Kim D, Lee S, Lee G, Lee SA, Kang LW, Kim D. (2022) Structural characterization and fatty acid epoxidation of CYP184A1 from Streptomyces avermitilis. Arch Biochem Biophys 727, 109338

Shimada T, Nagayoshi H, Murayama N, Sawai A, Kim V, Kim D, Yamazaki H, Guengerich FP, Takenaka S. (2022) Oxidation of 3'-methoxyflavone, 4'-methoxyflavone, and 3',4'-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13. Xenobiotica 52 (2), 134-145

2021년

Lee R., Kim V, Chun YJ., and Kim D. (2021) Structure-Functional Analysis of Human Cytochrome P450 2C8 Using Directed Evolution. Pharmaceutics 13(9):1429 

Kim D, Kim V, Tateishi Y, Guengerich FP. (2021) Cytochrome b5 binds tightly to several human cytochrome P450 enzymes. Drug Met Dis 49(10): 902-909 

Nagayoshi H, Murayama N, Takenaka S, Kim V, Kim D, Komori M, Yamazaki H, Guengerich FP, Shimada T. (2021) Roles of cytochrome P450 2A6 in the oxidation of flavone, 4´-hydroxyflavone, and 4´-, 3´-, and 2´-methoxyflavones by human liver microsomes. Xenobiotica 51 (9), 995-1009

Kim D, Kim V, McCarty KD, Guengerich FP. (2021) Tight binding of cytochrome b5 to cytochrome P450 17A1 is a critical feature of stimulation of C21 steroid lyase activity and androgen synthesis. J Biol Chem 296, 100571

Shimada T, Nagayoshi H, Murayama N, Takenaka S, Katahira J, Kim V, Kim D, Komori M, Yamazaki H, Guengerich FP. (2021) Liquid chromatography-tandem mass spectrometry analysis of oxidation of 2'-, 3'-, 4'- and 6-hydroxyflavanones by human cytochrome P450 enzymes. Xenobiotica 51 (2), 139–154

2020년

Kim V, Lim YR, Lee I, Lee J, Han S, Pham TV, Kim H, Lee R, Kang LW, Kim D. (2020) Structural insights into CYP107G1 from rapamycin producing Streptomyces rapamycinicus. Arch Biochem Biophys 692, 108544

Nagayoshi H, Murayama N, Tsujino M, Takenaka S, Katahira J, Kim V, Kim D, Komori M, Yamazaki H, Guengerich FP, Shimada T. (2020) Preference for O-demethylation reactions in the oxidation of 2'-, 3'-, and 4'-methoxyflavones by human cytochrome P450 enzymes. Xenobiotica 50 (10), 1158–1169

Kim H, Lee Y, Kim V, Lee R, Bae SK, Kwak MK, Lee SH, Kim D. (2020) Inhibition of cytochrome P450 2B6 by Astragalus extract mixture HT042. Toxicol Res 36 (3), 195–201

Kang TJ, Kim, JY, Ryu JH, Kim D, Lee CJ. (2020) A review on interaction between drug and healthy functional food, and the nutrient deficiency as the side effects of prescription drugs. Yakhak Hoeji 64 (2), 95-102

2019년

Cho MA, Yoon JG, Kim V, Kim H, Lee R, Lee MG, Kim D. (2019) Functional characterization of pharmacogenetic variants of human cytochrome P450 2C9 in Korean populations. Biomol Ther 27 (6) 577-583

Oh HA, Lee H, Park SY, Lim Y, Kwon O, Kim JY, Kim D, Jung BH. (2019) Analysis of plasma metabolic profiling and evaluation of the effect of the intake of Angelica keiskei using metabolomics and lipidomics. J Ethnopharmacol. 243, 112058

Park HG, Kim V, Kim H, Lee R, Cho MA, Park SW, Chun YJ, Kim D. (2019) CYP52A23 from Candida albicans and its Substrate Preference for Fatty Acid Hydroxylation. Arch. Biochem. Biophys 671, 27-34

Shin S, Kwon YJ, Ye DJ, Baek HS, Kwon TU, Kim D, Chun YJ.  (2019) Human steroid sulfatase enhances aerobic glycolysis through induction of HIF1<alpha> and glycolytic enzymesBiochim Biophys Acta Mol Basis Dis. 1865(9), 2464-2474

Nagayoshi H, Murayama N, Kakimoto K, Tsujino M, Takenaka S, Katahira J, Lim YR, Kim D, Yamazaki H, Komori M, Guengerich FP, Shimada T. (2019) Oxidation of Flavone, 5-Hydroxyflavone, and 5,7-Dihydroxyflavone to Mono-, Di-, and Tri-Hydroxyflavones by Human Cytochrome P450 Enzymes. Chem Res Toxicol 32(6) 1268-1280

Oh HA, Lee H, Kang KW, Im JH, Kim D, Yang HO, Jung BH (2019) Identification of interactions between multiple components in Socheongryong-tang using a plant profiling approach. Biomed Chromatogr 33 (6) e4500

Cho MA, Han S, Lim YR, Kim V, Kim H, and Kim D (2019) Streptomyces cytochrome P450 enzymes and their roles in the biosynthesis of macrolide therapeutic agents.  Biomol Ther 27 (2), 127-133

Nagayoshi H, Murayama N, Kakimoto K, Takenaka S, Katahira J, Lim YR, Kim V, Kim D, Yamazaki H, Komori M, Guengerich FP, Shimada T. (2019) Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes. Xenobiotica 49 (7) 791-802

Kakimoto K, Murayama N, Takenaka S, Nagayoshi H, Lim YR, Kim V, Kim D, Yamazaki H, Komori M, Guengerich FP, Shimada T (2019) Cytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone. Xenobiotica. 49 (2), 131-142

2018년

Lee, Y, Park HG,  Kim V, Cho MA, Kim H, Ho TH, Cho KS, Lee IS, and Kim D (2018) Inhibitory effect of α-terpinyl acetate on cytochrome P450 2B6 enzymatic activity. Chemico-Biological Interactions. 289, 90-97

 Kim V, Yeom S, Lee, Y, Park HG, Cho MA, Kim H, and Kim D (2018) In Vitro Functional Analysis of Human Cytochrome P450 2A13 Genetic Variants: P450 2A13*2, *3, *4, and *10. J. Toxicol. Environ. Health A. 81 (12), 493-501

 Shimada T, Murayama N, Kakimoto K, Takenaka S, Lim YR, Yeom S, Kim D, Yamazaki H, Guengerich FP, Komori M (2018) Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants. Xenobiotica 48 (6) 565-575

Jeong D, Park HG, Lim YR, Lee, Y, Kim V, Cho MA, and Kim D (2018) Terfenadine metabolism of human cytochrome P450 2J2 containing genetic variations (G312R, P351L and P115L) Drug Metab Pharmacokinet 33 (1) 61-66

2017년

  Shin S, Im HJ, Kwon YJ, Ye DJ, Baek HS, Kim D, Choi HK, Chun YJ (2017) Human steroid sulfatase induces Wnt/β-catenin signaling and epithelial-mesenchymal transition by upregulating Twist1 and HIF-1α in human prostate and cervical cancer cells. Oncotarget 8(37): 61604-61617 pubmed

  Albertolle ME, Kim D, Nagy LD, Yun CH, Pozzi A, Savas U, Johnson EF, Guengerich FP (2017) Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition. J Biol Chem 292(27) 11230-11242 pubmed

  Jo HY, Park SH, Le TK, Ma SH, Kim D, Ahn T, Joung YH, Yun CH (2017) Peroxide-dependent oxidation reactions catalyzed by CYP191A1 from Mycobacterium smegmatis. Biotechnol Lett39(8): 1245-1252 pubmed

Park HG, Lim YR, Han S, Jeong D, and   Kim D (2017) Enhanced Purification of Recombinant Rat NADPH-P450 Reductase by Using a Hexahistidine-tag.  J Microbiol Biotechnol  27 983-989pubmed

Oh HA, Lee H,  Kim D, and Jung BH  (2017) Development of GC-MS based cytochrome P450 assay for the investigation of multi-herb interaction. Anal Biochem 519 71-83 pubmed

Lim YR, Han S, Kim JH., Park, HG, Lee GY, Le TK, Yun CH, and Kim D (2017) Characterization of a biflaviolin synthase CYP158A3 from Streptomyces avermitilis and its role in the biosynthesis of secondary metabolites. Biomol Ther 25 (2) 171-176 pubmed

Han S, Pham TV, Kim JH, Lim YR, Park HG, Jeong D, Yun CH, Chun YJ, Kang LW, and Kim D  (2017) Structural insights into the binding of lauric acid to CYP107L2 from Streptomyces avermitilis. Biochem Biophys Res Commun 482 (4) 902-908 pubmed

  2014년

 Lee H, Kim JH, Han S, Lim YR, Park HG., Chun YJ, Park SW, Kim D (2014) Directed-evolution Analysis of Human Cytochrome P450 2A6 for Enhanced Enzymatic Catalysis. J. Toxicol. Environ. Health A. 77, 1409-1418

Kim D, Cha GS, Nagy LD, Yun CH, Guengerich FP (2014) Kinetic Analysis of Lauric Acid Hydroxylation by Human Cytochrome P450 4A11. Biochemistry 53, 6161-6172

Kang YP, Lee WJ, Hong JY, Lee SB, Park JH, Kim D, Park S, Park CS, Park SW, Kwon SW (2014) Novel Approach for Analysis of Bronchoalveolar Lavage Fluid (BALF) Using HPLC-QTOF-MS-Based Lipidomics: Lipid Levels in Asthmatics and Corticosteroid-Treated Asthmatic Patients. J. Proteome Res. 13, 3919-3929

Park, HG, Lim YR, Han, S, Kim D (2014) Expression and Characterization of Truncated Recombinant Human Cytochrome P450 2J2. Toxicol. Res. 30, 25-29

  2013년

Kim J, Lim, YR, Han S, Han JS, Chun YJ, Yun CH, Lee CH, Kim D (2013) Functional Influence of Human Cytochrome 2D6 Allelic Variations: P34S, E418K, S486T, and R296C. Arch. Pharm. Res. 36, 1500-1506

Choi S, Han S, Lee H, Chun YJ, Kim D (2013) Evaluation of Luminescent P450 Analysis for Directed Evolution of Human CYP4A11. Biomol. Ther. 21, 487-492

Sung, CH, Im HJ, Park N, Kwon Y, Shin S, Ye DJ, Cho NH, Park YS, Choi HK, Kim D, Chun YJ (2013) Induction of Steroid Sulfatase Expression in PC-3 Human Prostate Cancer Cells by Insulin-like Growth Factor II.  Toxicol. Lett. 223, 109-115

Han S, Kim K, Thakkar N, Kim D, Lee W (2013) Role of Hypoxia Inducible Factor-1α in the Regulation of the Cancer-Specific Variant of Organic Anion Transporting Polypeptide 1B3 (OATP1B3) in Colon and Pancreatic Cancer. Biochem. Pharmacol. 86, 816-823

Park SW, Lee E, Lee EJ, Kim HJ, Bae DJ, Han S, Kim D, Jang AS, Uh ST, Kim YH, Erle D, and Park CS (2013) Apolipoprotein A1 Potentiates LipoxinA4 Synthesis and Recovery of Allergen-Induced Disrupted Tight Junctions in the Airway Epithelium. Clin. Exp. Allergy 43, 914-927

Kwon YJ, Jung JJ, Park NH, Ye DJ, Kim D, Moon A, Chun YJ (2013) Annexin A5 as a New Potential Biomarker for Cisplatin-Induced Toxicity in Human Kidney Epithelial Cells. Biomol. Ther. 21, 190-195

Shimada T, Murayama N, Yamazaki H, Tanaka K, Takenaka S, Komori M, Kim D, Guengerich FP. (2013) Metabolic Activation of Polycyclic Aromatic Hydrocarbons and Aryl and Heterocyclic Amines by Human Cytochromes P450 2A13 and 2A6. Chem. Res. Toxicol. 26, 529-53

Shimada T, Kim D, Murayama N, Tanaka K, Takenaka S, Nagy LD, Folkman LM, Foroozesh MK, Komori M, Yamazaki H, Guengerich FP. (2013) Binding of Diverse Environmental Chemicals with Human Cytochromes P450 2A13, 2A6, and 1B1 and Enzyme Inhibition. Chem. Res. Toxicol. 26, 517-528

Kim J, Han S, Choi S, Park HG, Lim YR, Lee H, Kim D (2013) Analysis of Substrate Recognition Site 2 (SRS2) in Human Cytochrome P450 1A2 Using Whole-plasmid Random Mutagenesis. Mol. Cell. Toxicol. 9, 9-14

2012년

Lim YR, Hong MK, Kim JK, Doan TT, Kim DH, Yun CH, Chun YJ, Kang LW, Kim D. (2012) Crystal structure of cytochrome P450 CYP105N1 from Streptomyces coelicolor, an oxidase in the coelibactin siderophore biosynthetic pathway. Arch. Biochem. Biophys. 528, 111-117 (*highlighted as a cover)

Im H-J, Park N-H, Kwon Y-J, Shin S, Kim D, and Chun Y-J (2012) Bacterial Lipopolysaccharides Induce Steroid Sulfatase Expression and Cell Migration through IL-6 Pathway in Human Prostate Cancer Cells. Biomol. Ther. 20, 556-561

Jeon B, Hwang YK, Lee SY, Kim D, Chung C, Han J-S. (2012) The role of basolateral amygdala in the regulation of stress-induced phosphorylated extracellular signal-regulated kinase expression in the hippocampus. Neuroscience 224, 191-201

Han, S., Choi, S., Chun, Y.-J., Yun, C.-H., Lee, C. H., Shin, H. J., Na, H. S., Chung, M. W., and Kim, D., (2012) Functional Characterization of Allelic Variants of Polymorphic Human Cytochrome P450 2A6 (CYP2A6*5, *7, *8, *18, *19, and *35). Biol. Pharm. Bull. 35, 394–399

Lee, H., Park, H.-G., Lim Y.-R., Lee, I.-S., Kim, B. J., Chun, Y.-J., and Kim, D. (2012) Functional Expression and Characterization of Recombinant NADPH-P450 Reductase from Malassezia globosa. J. Microbiol. Biotechnol. 22, 145–150

2011년

Lee, I.-S., and Kim, D. (2011) Polymorphic Metabolism by Functional Alternations of Human Cytochrome P450 Enzymes. Arch. Pharm. Res. 34, 1799–1816

Lim, C. S., Hwang, Y. K., Kim, D., Cho, S. H., Banuelos, C., Bizonand, J. L., and Han, J.-S. (2011) Increased Interactions between PKA and NF-κB Signaling in the Hippocampus Following Loss of Cholinergic Input. Neuroscience 192, 485–493

Park, H.-G., Lee, I.-S., Chun, Y.-J., Yun, C.-H., Johnston, J. B., Ortiz de Montellano, P. R.,  and Kim, D. (2011) Heterologous Expression and Purification of Sterol 14a-Demethylase, CYP51F1 from Candida albicans. Arch. Biochem. Biophys. 509, 9-15

Lee, Y. W., Byun, H. J., Kim, B. J., Kim, D. H., Lim, Y.Y., Lee, J. W., Kim, M. N., Kim, D., Chun, Y.-J., Mun, S. K., Kim, C. W., Kim, S. E., Hwang JS. (2011) Distribution of Malassezia Species on the Scalp in Korean Seborrheic Dermatitis Patients. Ann. Dermatol. 23, 156-161

Lee, J. W., Lee, H. I., Kim, M. N., Kim, B. J,, Chun, Y.-J., Kim, D. (2011) Topical Photodynamic Therapy with Methyl Aminolevulinate May Be an Alternative Therapeutic Option for the Recalcitrant Malassezia folliculitis. Int. J. Dermatol. 50, 488-490

Lee, H. J., Park, M. K., Park, Y. R., Kim, D., Chun, Y.-J., Yun, C.-H., Shin, H. J., Na, H. S., Chung, M. W., and Lee, C. H. (2011) Expression of CYP2A6, CYP2D6 and CYP4A11 Polymorphisms in COS7 Mammalian Cell Line. Toxicol. Res. 27, 25-29

Kim, D., Lim Y.-R., Ohk, S. O., Kim, B. J., and Chun, Y.-J. (2011) Functional Expression of CYP51 Involved in Lanosterol Demethylation in a Dandruff-causing Malassezia globosa. FEMS Yeast Res. 11, 80-87

2010년

Eun, C.-Y, Han, S., Lim Y.-R., Park, H.-G., Han, J.-S., Cho, K. S., Chun, Y.-J., and Kim, D. (2010) Bioactivation of Aromatic Amines by Human CYP2W1, An Orphan Cytochrome P450 Enzyme. Toxicol. Res. 26, 171-175

Lee, M. J., Park, M. S., Hwang, S., Hong, Y. K., Choi, G., Suh, Y. S., Han, S. Y., Kim, J. Y., Jeun, J., Oh, C.-T., Lee, S. J., Han, S.-J., Kim, D., Kim, E.-S., Jeong, G., and Cho, K. S. (2010) Dietary Hempseed Meal Intake Increases Body Growth and Shortens Larval Stage via Upregulation of Cell Growth and Ecdysone Level in Drosophila melanogaster. Mol. Cells 30, 29-36

Park, H.-G., Lim Y.-R., Eun, C.-Y, Han, S., Han, J.-S., Cho, K. S., Chun, Y.-J., and Kim, D. (2010) Candida albicans NADPH-P450 Reductase: Expression, Purification, and Characterization of Recombinant Protein. Biochem. Biophys. Res. Comm. 396, 534-538

Park, S.-H., Kim, D.-H., Kim D., Kim, D.-H., Jung, H.-C., Pan, J.-G., Chi Y.-T., Ahn T., Kim, D., and Yun C.-H. (2010) Engineering bacterial cytochrome P450 (P450) BM3 into a prototype with human P450 enzyme activity using indigo formation. Drug Metab. Dispos. 38, 732-739

Lim, Y.-R., Eun, C.-Y., Park, H.-G., Han, S., Han, J.-S., Cho, K. S., Chun, Y.-J., and Kim, D. (2010) Regioselective Oxidation of Lauric Acid by CYP119, An Orphan Cytochrome P450 from Sulfolobus acidocaldarius. J. Microbiol. Biotechnol. 20, 574-578

Lee, E. C., Ohk, S. O., Suh B. Y., Park N., Kim, B. J., Kim, D., and Chun, Y.-J. (2010) Cloning and Expression in Pichia pastoris of a New Cytochrome P450 Gene from a Dandruff-causing Malassezia globosa. Toxicol. Res. 26, 47-52

2009년

Kim, B. J., Lee, E. C., Lim, Y. Y., Kim, D., and Chun, Y.-J. (2009) Optimal Culture Condition for Antifungal Susceptibility Tests of Malassezia globosa. Kor. J. Med. Mycol. 14, 182-189

Kim, D., and Ortiz de Montellano, P. R. (2009) Tricistronic Overexpression of Cytochrome P450cam, Putidaredoxin, and Putidaredoxin Reductase Provides a Useful Cell-based Catalytic System. Biotechnol. Lett. 31, 1427-1431

Chun, Y.-J., Oha, Y.-K., Kim, B. J., Kim, D., Kim, S. S., Choi, H. K., and Kim, M.-Y. (2009) Potent Inhibition of Human Cytochrome P450 1B1 by Tetramethoxystilbene. Toxicol. Lett. 189, 84-89

Han, S., Eun, C.-Y., Han, J.-S., Chun, Y.-J., Kim, D.-H., Yun, C. H., and Kim, D. (2009) Self-Sufficient Catalytic System of Human Cytochrome P450 4A11 and NADPH-P450 Reductase. Biomol. Ther. 17, 156-161

Kim, D., Lim, Y.-R., Park, H. G., Kim, B. J., and Chun, Y.-J. (2009) Differential Display Analysis of 2,3,7,8-Tetrachlorodibenzo-p-dioxin Identified Induction of Ras-related Nuclear Protein Binding Protein2 (RanBP2) Gene.  Toxicol. Res. 25, 35-40

2008년

Kim, D., Heo, Y.-S., and Ortiz de Montellano, P. R. (2008) Efficient Catalytic Turnover of Cytochrome P450cam is Supported by a T252N Mutation. Arch. Biochem. Biophys. 474, 150-156

2007년

Kim, D., and Chun, Y.-J. (2007) Human Cytochrome P450 Metabolic Activation in Chemical Toxicology. J. Toxicol. Pub. Health 23, 189-196

Kim, D., Cryle, M. J.,  De Voss, J. J., and Ortiz de Montellano, P. R. (2007) Functional Expression and Characterization of Cytochrome P450 52A21 from Candida albicans: Fatty acid ω-hydroxylation in a new protein framework. Arch. Biochem. Biophys. 464, 213-220

before 2006 년

Kim, D., Yukl, E. T., Moënne-Loccoz, P., and Ortiz de Montellano, P. R. (2006) Fungal Heme Oxygenases: Functional expression and characterization of Hmx1 from Saccharomyces cerevisiae and CaHmx1 from Candida albicans. Biochemistry 45, 14772-14780

Kim, D., Wu, Z. -L., and Guengerich, F. P. (2005) Analysis of Coumarin 7-Hydroxylation Activity of Cytochrome P450 2A6 Using Random Mutagenesis. J. Biol. Chem. 280, 40319-40327  (*highlighted as a cover of ASBMB Today 2005 December issue)

Kim, D., and Guengerich, F. P. (2005) Cytochrome P450 Activation of Arylamines and Heterocyclic Amines. Annual. Rev. Pharmacol. 45, 27-49

Kim, D., and Guengerich, F. P. (2004) Enhancement of 7-Methoxyresorufin O-Demethylation Activity of Human Cytochrome P450 1A2 by Molecular Breeding. Arch. Biochem. Biophys. 432, 102-108

Kim, D., Kadlubar, F. F., Teitel, C. H., and Guengerich, F. P. (2004) Formation and Reduction of Aryl and Heterocyclic Nitroso Compounds and Significance in the Flux of Hydroxylamines. Chem. Res. Toxicol. 17, 529-536

Kim, D., and Guengerich, F. P. (2004) Selection of Human Cytochrome P450 1A2 Mutants with Enhanced Catalytic Activity for Heterocyclic Amine N-Hydroxylation. Biochemistry 43, 981-988

Zhou, H., Josephy, P. D., Kim, D., and Guengerich, F. P. (2004) Functional Characterization of Four Allelic Variants of Polymorphic Human Cytochrome P450 1A2. Arch. Biochem. Biophys. 422, 23-30

Guengerich, F. P., Chun, Y.-J., Kim, D., Gillam, E. M. J., and Shimada, T. (2003) Cytochrome P450 1B1: A Target for Inhibition in Anticarcinogenesis Strategies. Mut. Res. 523-524, 173-182

Guengerich, F. P., Wheeler, J. B., Chun, Y.-J., Kim, D., Shimada, T., Aryal, P., Oda, Y., and Gillam, E. M. J. (2002) Use of Heterologously-expressed Cytochrome P450 and Glutathione Transferase Enzymes in Toxicity Assays. Toxicology 181-182, 261-264

Kim, D., and Guengerich, F. P. (2002) Random Mutagenesis by Whole-Plasmids PCR Amplification. PCR Cloning Protocols, 2nd Edition (Chen, B-Y., and Janes, H.W., Eds) Methods in Molec. Biol. 192,241-245

Chun, Y.-J., Kim, S., Kim, D., Lee, S.-K and Guengerich, F. P. (2001) A New Selective and Potent Inhibitor of Human P450 1B1 and Its Application to Antimutagenesis. Cancer Res. 61, 8164-8170

Guengerich, F. P., Parikh, A., Yun, C., Kim, D., Nakamura, K., Notley, L. M. and Gillam, E. M. J. (2000) What Makes P450s Work? Searches for Answers with Known and New P450s. Drug Metab. Rev. 32, 267-281

Gillam, E. M. J., Aguinaldo, A-M., Notley, L. S., Kim, D., Mundows, R. G., Volkov, A. A., Arnold, F. H., Soucek, P., DeVoss, J., and Guengerich, F. P. (1999) Formation of Indigo by Recombinant Mammalian Cytochrome P450. Biochem. Biophys. Res. Comm. 265, 469-472